Adolfo garcia sastre biography definition wikipedia
Adolfo García-Sastre
Spanish and American academic
Adolfo García-Sastre,(born in Burgos, 10 October ) is a Spanish professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York City.
His research into the biology of influenza viruses has been at the forefront of medical advances in epidemiology.[1]
García-Sastre is the author of more than publications.
Biography
Born in Burgos, Spain, García-Sastre earned his PhD at the University of Salamanca.[citation needed] His research interest has been focused on the molecular biology of influenza viruses and several other negative-strandRNA viruses.
His contributions to his field have included the generation and evaluation of influenza virus vectors as potential vaccine candidates against infectious diseases, including malaria and AIDS, as well as the development (with Peter Palese) of the first reverse-genetic approaches for the production of infectious recombinant influenza viruses from plasmidDNA – research which has resulted in techniques which are now routinely used with many negative strand RNA viruses.
He was the first to identify the biological role of the non-structural NS1 Influenza Protein during infection, the first to describe and provide a molecular analysis of a viral-encoded IFN antagonist among negative strand RNA viruses,[1] and the first to demonstrate that the M1 protein of the influenza virus determines its morphology.
In , as principal investigator of an NIAID program project grant, García-Sastre and his team made headlines when they reconstructed the extinct pandemic influenza virus.[2]
García-Sastre is an editor for the Journal of Experimental Medicine and PLOS Pathogens, and he sits on the editorial boards of the Journal of Virology, Virology, Virus Research and the Journal of General Virology.
In , he co-organized the International Course on Viral Vectors in Heidelberg, Germany, which was sponsored by the Federation of European Biochemical Societies (FEBS), as well as the first Research Conference on Orthomyxoviruses, also in , which was held in the Netherlands and sponsored by the European Scientific Working Group on Influenza.[2] He is a co-founder of Vivaldi Biosciences and a member of the company's Scientific Advisory board[3] and is the leader of the basic research component on the NIAID-funded Viral Therapeutics and Pathogenesis of the North East Biodefense Center proposal.[4] He was among the first members of the Vaccine Study Section of the National Institutes of Health.[5] He is also principal investigator for the Center for Research on Influenza Pathogenesis, one of five NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS).
Adolfo garcia sastre biography definition us history For the past 20 years, Dr. He has made major contributions to the influenza virus field, including the development of reverse genetics techniques allowing the generation of recombinant influenza viruses from plasmid deoxyribonucleic acid DNA through studies in collaboration with Peter Palese, PhD ; the generation and evaluation of influenza virus vectors as potential vaccine candidates against different infectious diseases, including malaria and AIDS; the identification of the biological role of the non-structural protein NS1 of influenza virus during infection: the inhibition of the type I interferon IFN system; and the reconstruction and characterization of the extinct pandemic influenza virus of These studies led to the generation of attenuated influenza viruses containing defined mutations in their IFN antagonist protein that might prove to be optimal live vaccines against influenza. In addition, Dr. He is a member of the scientific advisory board of Keystone Symposia and, in , co-organized both the international course on Viral Vectors, sponsored by the Federation of European Biochemical Societies, and the first Research Conference on Orthomyxoviruses, sponsored by the European Scientific Working Group on Influenza.He was elected to the National Academy of Sciences in [6]
Patents
García-Sastre holds 7 patents:[7]
| Number | Title |
|---|---|
| Recombinant newcastle disease virus RNA expression systems and vaccines[8] | |
| Novel methods and Interferon deficient substrates for the propagation of virues[9] | |
| Recombinant negative strand RNA virus expression systems and vaccines[10] | |
| Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals[11] | |
| Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents[12] | |
| Genetically Engineered Swine Influenza Virus and Uses Thereof[13] | |
| Genetically Engineered Equine Influenza Virus and Uses Thereof[14] |
Publications
Partial List:
- Mueller, S.
N.; Langley, W. A.; Carnero, E.; Garcia-Sastre, A.; Ahmed, R. (). "Immunization with Live Attenuated Influenza Viruses That Express Altered NS1 Proteins Results in Potent and Protective Memory CD8+ T-Cell Responses". Journal of Virology. 84 (4): – doi/JVI PMC&#; PMID&#;
- Martinez-Sobrido, L.; Cadagan, R.; Steel, J.; Basler, C.
F.; Palese, P.; Moran, T. M.; Garcia-Sastre, A. ().
Adolfo garcia sastre biography definition psychology: Adolfo García-Sastre, (born in Burgos, 10 October ) is a Spanish professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York City.
"Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection of Influenza Virus Neutralizing Antibodies". Journal of Virology. 84 (4): – doi/JVI PMC&#; PMID&#;
- Nistal-Villán, E.; García-Sastre, A. (). "Attacking the flu: New prospects for the rational design of antivirals".Karla kirkegaard He pioneered the use of plasmid-based reverse genetics to study the molecular biology and pathogenesis of influenza viruses and to generate improved influenza virus vaccines. He also discovered viral interferon antagonists, first in influenza virus, and also in ebolavirus, dengue virus, and other hemorrhagic fever viruses. His publication in Science on the reconstruction and characterization of the pandemic influenza virus of was awarded with the distinction of the paper of the year by Lancet. He was a postdoctoral fellow at the Department of Microbiology of the Icahn School of Medicine at Mount Sinai where he joined the faculty in A major focus of the lab is on influenza virus research.
Nature Medicine. 15 (11): – doi/nm PMC&#; PMID&#;
- Babiuk, S.; Albrecht, R.; Berhane, Y.; Marszal, P.; Richt, J. A.; Garcia-Sastre, A.; Pasick, J.; Weingartl, H. (). " and H1N1 influenza viruses are not pathogenic in birds". Journal of General Virology. 91 (2): – doi/vir PMC&#; PMID&#;
- Baum, A.; García-Sastre, A.
(). "Induction of type I interferon by RNA viruses: Cellular receptors and their substrates". Amino Acids. 38 (5): – doi/s PMC&#; PMID&#;
- Tscherne, D. M.; Manicassamy, B.; García-Sastre, A. (). "An enzymatic virus-like particle assay for sensitive detection of virus entry". Journal of Virological Methods.
(2): – doi/et PMC&#; PMID&#;
- Gannagé, M.; Dormann, D.; Albrecht, R.; Dengjel, J. R.; Torossi, T.; Rämer, P. C.; Lee, M.; Strowig, T.; Arrey, F.; Conenello, G.; Pypaert, M.; Andersen, J.; García-Sastre, A.; Münz, C. (). "Matrix Protein 2 of Influenza a Virus Blocks Autophagosome Fusion with Lysosomes".
- Garcia-Sastre Laboratory
- Adolfo Garcia-Sastre (born October 10, 1964), Spanish ...
- Adolfo García-Sastre – NAS - National Academy of Sciences
- Settings
Cell Host & Microbe. 6 (4): – doi/ PMC&#; PMID&#;
- Steel, J.; Staeheli, P.; Mubareka, S.; Garcia-Sastre, A.; Palese, P.; Lowen, A. C. (). "Transmission of Pandemic H1N1 Influenza Virus and Impact of Prior Exposure to Seasonal Strains or Interferon Treatment". Journal of Virology.
84 (1): 21– doi/JVI PMC&#; PMID&#;
- Richt, J. E. A.; García-Sastre, A. (). "Attenuated Influenza Virus Vaccines with Modified NS1 Proteins". Vaccines for Pandemic Influenza. Current Topics in Microbiology and Immunology. Vol.&#; pp.&#;– doi/_9. ISBN&#;. PMID&#;
- Kochs, G.; Martinez-Sobrido, L.; Lienenklaus, S.; Weiss, S.; Garcia-Sastre, A.; Staeheli, P.
(). "Strong interferon-inducing capacity of a highly virulent variant of influenza a virus strain PR8 with deletions in the NS1 gene". Journal of General Virology. 90 (12): – doi/vir PMC&#; PMID&#;
- Guo, H.; Kumar, P.; Moran, T. M.; Garcia-Sastre, A.; Zhou, Y.; Malarkannan, S.
(). "The functional impairment of natural killer cells during influenza virus infection". Immunology and Cell Biology. 87 (8): – doi/icb PMC&#; PMID&#;
- Martinez-Sobrido, L.; Emonet, S.; Giannakas, P.; Cubitt, B.; Garcia-Sastre, A.; De La Torre, J. C. (). "Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus".
Journal of Virology. 83 (21): – doi/JVI PMC&#; PMID&#;
- Billharz, R.; Zeng, H.; Proll, S. C.; Korth, M. J.; Lederer, S.; Albrecht, R.; Goodman, A. G.; Rosenzweig, E.; Tumpey, T. M.; García-Sastre, A.; Katze, M. G. (). "The NS1 Protein of the Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways".
Journal of Virology. 83 (20): – doi/JVI PMC&#; PMID&#;
- Bolland, S.; Garcia-Sastre, A. (). "Vicious circle: Systemic autoreactivity in Ro52/TRIMdeficient mice". Journal of Experimental Medicine. (8): – doi/jem PMC&#; PMID&#;
- Kuri, T.; Zhang, X.; Habjan, M.; Martinez-Sobrido, L.; Garcia-Sastre, A.; Yuan, Z.; Weber, F.
(). "Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation". Journal of General Virology. 90 (11): – doi/vir PMC&#; PMID&#;
- Frias-Staheli, N.; Giannakopoulos, N. V.; Kikkert, M.; Taylor, S. L.; Bridgen, A.; Paragas, J.; Richt, J.
A.; Rowland, R. R.; Schmaljohn, C. S.; Lenschow, D. J.; Snijder, E. J.; García-Sastre, A.; Virgin, H. W. (). "Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISGDependent Innate Immune Responses". Cell Host & Microbe. 2 (6): – doi/ PMC&#; PMID&#;
- Vigil, A.; Park, M.
-S.; Martinez, O.; Chua, M. A.; Xiao, S.; Cros, J. F.; Martínez-Sobrido, L.; Woo, S. L. C.; García-Sastre, A. (). "Use of Reverse Genetics to Enhance the Oncolytic Properties of Newcastle Disease Virus". Cancer Research. 67 (17): – doi/CAN PMID&#;
- Mibayashi, M.; Martinez-Sobrido, L.; Loo, Y.
-M.; Cardenas, W. B.; Gale, M.; Garcia-Sastre, A. (). "Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza a Virus". Journal of Virology. 81 (2): – doi/JVI PMC&#; PMID&#;
- Tumpey, T. M.; Maines, T. R.; Van Hoeven, N.; Glaser, L.; Solórzano, A.; Pappas, C.; Cox, N.
J.; Swayne, D. E.; Palese, P.; Katz, J. M.; García-Sastre, A. (). "A Two-Amino Acid Change in the Hemagglutinin of the Influenza Virus Abolishes Transmission". Science. (): – BibcodeSciT. doi/science PMID&#; S2CID&#;
- Richt, J. A.; Lekcharoensuk, P.; Lager, K. M.; Vincent, A. L.; Loiacono, C.
M.; Janke, B. H.; Wu, W. -H.; Yoon, K. -J.; Webby, R. J.; Solórzano, A.; García-Sastre, A. (). "Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine". Journal of Virology. 80 (22): – doi/JVI PMC&#; PMID&#;
- Tumpey, T. M.; Basler, C. F.; Aguilar, P. V.; Zeng, H.; Solórzano, A.; Swayne, D.
E.; Cox, N. J.; Katz, J. M.; Taubenberger, J. K.; Palese, P.; García-Sastre, A. ().
Adolfo garcia sastre biography definition and example
For the past 25 years, his research interest has been focused on the molecular biology of influenza viruses and several other negative strand RNA viruses. During his post-doctoral training in the early s, he developed, for the first time, novel strategies for expression of foreign antigens by a negative strand RNA virus, influenza virus. He has made major contributions to the influenza virus field, including 1 the development of reverse genetics techniques allowing the generation of recombinant influenza viruses from plasmid DNA, studies in collaboration with Dr. Palese ; 2 the generation and evaluation of negative strand RNA virus vectors as potential vaccine candidates against different infectious diseases, including malaria and AIDS, and 3 the identification of the biological role of the non-structural protein NS1 of influenza virus during infection: the inhibition of the type I interferon IFN system. His studies provided the first description and molecular analysis of a viral-encoded IFN antagonist among negative strand RNA viruses."Characterization of the Reconstructed Spanish Influenza Pandemic Virus". Science. (): 77– BibcodeSciT. CiteSeerX&#; doi/science PMID&#; S2CID&#;
- Munoz-Jordan, J. L.; Sánchez-Burgos, G. G.; Laurent-Rolle, M.; García-Sastre, A. (). "Inhibition of interferon signaling by dengue virus". Proceedings of the National Academy of Sciences.
(24): – BibcodePNASM. doi/pnas PMC&#; PMID&#;
- Basler, C. F.; Reid, A. H.; Dybing, J. K.; Janczewski, T. A.; Fanning, T. G.; Zheng, H.; Salvatore, M.; Perdue, M. L.; Swayne, D. E.; García-Sastre, A.; Palese, P.; Taubenberger, J. K. (). "Sequence of the pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the NS genes".
Proceedings of the National Academy of Sciences.
Adolfo garcia sastre biography definition His research into the biology of influenza viruses has been at the forefront of medical advances in epidemiology. His contributions to his field have included the generation and evaluation of influenza virus vectors as potential vaccine candidates against infectious diseases, including malaria and AIDS , as well as the development with Peter Palese of the first reverse-genetic approaches for the production of infectious recombinant influenza viruses from plasmid DNA — research which has resulted in techniques which are now routinely used with many negative strand RNA viruses. He was the first to identify the biological role of the non-structural NS1 Influenza Protein during infection, the first to describe and provide a molecular analysis of a viral-encoded IFN antagonist among negative strand RNA viruses, [ 1 ] and the first to demonstrate that the M1 protein of the influenza virus determines its morphology. He was elected to the National Academy of Sciences in Contents move to sidebar hide.98 (5): – doi/pnas PMC&#; PMID&#;
- Garciasastre, A. (). "Inhibition of Interferon-Mediated Antiviral Responses by Influenza a Viruses and Other Negative-Strand RNA Viruses". Virology. (2): – doi/viro PMID&#;
- Fodor, E.; Devenish, L.; Engelhardt, O.
G.; Palese, P.; Brownlee, G. G.; García-Sastre, A. (). "Rescue of Influenza a Virus from Recombinant DNA". Journal of Virology. 73 (11): – doi/JVI PMC&#; PMID&#;